status epilepticus
Conditions
Interventions
Group 1:valproate
Group 2:phenobarbital
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The operational definition of GCSE is defined as more than five minutes of continuous seizures or two or more discrete seizures between which there is incomplete recovery of consciousness; 2. All patients were 18 years or older and were given intravenously (IV) diazepam (DZP)(0.2mg/kg) twice but GCSE failed to be terminated (seizures and/or continuous epileptic discharges on EEG were still presented within 20min after IV DZP).
Exclusion criteria
Exclusion criteria: 1. Unstable vital signs, such as a pulse of <60 beats per min, a systolic blood pressure of <90 mmHg, or an arterial blood oxygen saturation of <90%; 2. Severe cardiac arrhythmias (second- or third-degree atrioventricular block, sustained ventricular tachyarrhythmia); 3. Severe chronic obstructive pulmonary disease; 4. severe disfunction of liver with hepatic encephalopathy; 5. A neurologic emergency requiring immediate surgical intervention; 6. Pregnancy or breast feeding; 7. Hypersensitivity to AEDs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effective rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| prognosis; | — |
Countries
China
Contacts
Public ContactSu Yingying
Outcome results
None listed