Alzheimer's disease (AD)
Conditions
Interventions
AD intervention group:folic acid, 1.25mg/day, oral, six months
control:without folic acid
Sponsors
Tianjin Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients meet a probable Alzheimers disease of NIA-AA diagnostic criteria in 2011 who were diagnosed by 2 neurology physician; 2. All were examined detailed history, neurologic examination, neuropsychological test, PET, MRI and the necessary laboratory examination; 3. All were native Chinese, right-handed, sane and cooperative; 4. Aged from 40 to 90 years old.
Exclusion criteria
Exclusion criteria: 1. Neurological examination found the sign of local central nerve obstruction such as obvious paralysisunilateral sensory disturbance and aphasia etc, history of cerebrovascular diseases (hemorrhagic and ischemic stroke), brain injury or bone fracture; 2. Medical diseases such as asthmatic bronchitis, severe hypertension, angina pectoris and severe infection; 3. Psychotic patients with evident anxiety and depressed emotion and subjects with endocrine system history of disease(hyperthyroidism, thyroid hypofunction, systemic lupus eythematosus, rheumatoid arthritis); 4. Newly discovered or advanced tumor; 5. Visual perception, auditory perceptual disorders or languages communication difficulties, all of which may influence measurement of cognitive function; 6. Alcohol dependence and other psychoactive substance abuse such as antipsychotic drug,benzodiazepines or taking medicine influencing cognitive function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood gene expression related;serum folate, plasma homocysteine, S-adenosyl homocysteine;MMSE scores, ADL scale; | — |
Countries
China
Contacts
Public ContactGuowei Huang
Outcome results
None listed