end-stage liver disease
Conditions
Interventions
Experimental group:propofol postconditioning
Control:not treated by propofol postconditioning
Sponsors
Department of Anesthesiology in the Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) >18 years of age; (2) can be acquired informed consent; (3) without any other diagnostic organ dysfunction;who are scheduled for allogeneic orthotopic liver transplantation.
Exclusion criteria
Exclusion criteria: (1) >65 years of age; (2) cannot be acquired informed consent; (3) are accompanied with other diagnostic organ dysfunction; (4) need any other operation together except liver transplantation; (5) have massive haemorrhae (>10000ml) during the surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| perioperative adverse events;duration time of ICU;survival rate in half year, 1 and 3 year;pathologic change;expression of Nrf2, Brg1 and antioxidase;liver function; | — |
Countries
China
Contacts
Public ContactHei Ziqing
Outcome results
None listed