Efficacy of Helicobacter pylori eradication therapy concomitantly with probiotics in relation to changes in the intestinal microbiota

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-13003228

Enrollment

Unknown

Registered

2013-05-23

Start date

2013-05-24

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

duodenal ulcer with H.pylory infection

Interventions

experimental group:Esomeprazole+ Clarithromycin+ Amoxicillin+probiotic

control group:Esomeprazole+ Clarithromycin+ Amoxicillin

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 65 years old, Gender: male or female; 2. Active duodenal ulcer find by gastroscopy; 3. Exist H.pylori infection; 4. No other disease history; 5. No other medication history before one month of the treatment and during the treatment; 6. Able and willing to provide signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients who dont have H.pylory infection; 2. Allergic to PPI,antibiotics and probiotics; 3. Patients who do not seek medication; 4. patients who take other drugs which can affect intestinal microbiota; 5. Patients who have other serious diseases; 6. Pregnant or lactating women; 7. Patients who had attend other clinical trails.

Design outcomes

Primary

Measure	Time frame
intestinal microbiota;	—

Countries

China

Contacts

Public ContactYang Yunsheng

sunny301ddc@126.com+86 010 55499007

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026