Estimating the plasma effect-site equilibrium rate constant (Ke0) of propofol in anesthesia induction and maintenance stage

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-13003164

Enrollment

Unknown

Registered

2013-02-26

Start date

2013-04-30

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The plasma effect-site equilibrium rate constant (Ke0) of propofol in anesthesia

Interventions

induction stage:1.5mg/kg propofol

maintaintion stage small dosage:0.4mg/kg propofol

maintaintion stage large dosage:0.8mg/kg propofol

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 65 years; 2. SGPT and BUN Cr are fine; 3. general surgery; 4. well-cooperated; 5. informed consent.

Exclusion criteria

Exclusion criteria: 1. participated in other clinical trials four weeks ago the start of this study; 2. Taking neurological drugs 2 weeks ago the beginning of the experiment; 3. Respiratory depression, (lung) airway obstruction or hypoxia; 4. Cardiac disorders (II level and above level II cardiac function; 5. Liver, kidney dysplasia (indicators higher than the normal twice); 6. Brain disease, abnormal judgment ability; 7.allergy to Propofol; 8. Drugs and/or alcohol abuse; 9. Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
bispectral index;	—

Countries

China

Contacts

Public ContactQi Wu

wuqimed@126.com+86 18660150557

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026