Functional Dyspepsia with Weight loss
Conditions
Interventions
A:Group A is treated with conventional therapy during 8 weeks
B:Group B is treated with conventional therapy in combination with Paroxetine during 8 weeks
C:Group C is treated with conventional therapy in combination with Mirtazapine during 8 weeks
Sponsors
Guangzhou Nansha Central Hospital, Guangzhou First People's Hospital Affiliated to Guangzhou Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients are from gastroenterology unit in Guangzhou Nansha Central Hospital who conform to the Rome III criteria for functional dyspepsia (patients must have one or more of following symptoms for at least 3 months with symptom onset at least 6 months previously: bothersome postprandial fullness, early satiation, epigastric pain, epigastric burning with no evidence of structural disease, including the use of upper endoscopy, which is likely to explain the symptoms); 2. Patients with a weight loss of >=5% of the initial body weight since the onset of symptoms; 3. The diagnosis of depression is made by psychiatrists accorrding to CCMD-3 and the scores of HAMD over 18; 4. Aged from 18 years to 65 years; 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. organic diseases found during gastroscopy examination, such as peptic ulcers, atrophy or erosive gastroduodenal lesions, tumors,and esophagitis; 2. Laboratory, B ultrasonic, X-ray examination have found liver; gall; Pancreas, Spleen and bowel organic disease; 3. dyspepsia symptoms and weight loss that were explained by metabolic or infectious diseases such as diabetes, hyperthyroidism, tuberculosis; 4. anorexia nervosa and patients with body weight management; 5. Aged 65 years; 6. Pregnancy or breast feeding; 7. Disabled patients; 8. patients is Concurrently undergoing other drugs in clinical research or nearly half a month used the Similar drugs; 9. In a severe anxiety or depression state, or suicidal tendencies; 10. current use of non-steroidal anti-inflammatory drugs, steroids, or drugs affecting gastric acid secretion; 11. Contraindications or careful with Paroxetine and mirtazapine including: hypersensitivity; liver dysfunction or renal Failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Nepean Dyspepsia Index (NDI)-symptom checklist;The Hamilton Rating Scale of Depression (HAMD);The number of barium strip expelled from stomach after 3 hours;Body weight;Appetite;Gastrointestinal hormone;Clinical Global Impression (CGI);side effect; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Hamilton Rating Scale of Anxiety (HAMA);The Pittsburgh Sleep Quality Index (PSQI);The Nepean Dyspepsia Index-quality of life (NDI-QOL); | — |
Countries
China
Contacts
Public ContactLin Jia
Outcome results
None listed