Neurocritical disease
Conditions
Interventions
PS reduction group:Gradual pressure support (PS) reduction before spontaneous breathing trial (SBT)
SBT group:Initial SBT
Sponsors
Dept. of Neurology, Nanfang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. aged >=18 years; 2. being admitted into neurocritical care unit (NCU) for primary central nervous system (CNS) or peripheral nervous system (PNS) diseases; 3. mechanical ventilation for150200mmHgpositive end-expiratory pressure (PEEP)=7.25); (3) hemodynamic stability, as defined by the absence of active myocardial ischemia and the absence of clinically significant hypotension (ie, a condition requiring no vasopressor therapy or therapy with only low-dose vasopressors such as dopamine or dobutamine =60mmHg (when ICP measured).
Exclusion criteria
Exclusion criteria: 1. end-stage diseases; 2. withdraw of treatment; 3. lack of informal consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of weaning;Rate of successful weaning trial; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation;Length of NCU stay;Length of hospital stay;Costs of hospital stay;Incidence of VAP;Mortality during NCU;Mortality during hospitalization; | — |
Contacts
Public ContactShengnan Wang
Outcome results
None listed