Parkinson's disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients will be included if they have all the following: a. Meet UKPDBB criteria; b. Age of 18 to 80 years (inclusive); c. Meet the diagnosis of DSQ; d. Stable treatment with levodopa, alone or in combination with other antiparkinsonian drugs over the last 2 months; e. A PD rating of 1.5 to 4 on the Modified Hoehn and Yahr scale; f. Normal liver and renal function in blood test.
Exclusion criteria
Exclusion criteria: Patients will be excluded if they have one or more of the following: a. Atypical or secondary Parkinsonism; b. Use of antidepressants during the preceding month; c. History of psychosis; d. Suicide attempts during the preceding 12 months, or a severe suicidal tendency (score ? 3 on HAM-D item 3, suicide); e. Mini-Mental State Examination (MMSE) < 24; f. Severe diseases (i.e. cancer and acute present asthma); f. Allergy to Chinese herbal medicine; g. Pregnancy or are breast feeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NMSS;MDS-UPDRS part; | — |
Secondary
| Measure | Time frame |
|---|---|
| PDQ-39;DSQ;MDS-UPDRS part 2-4;SF-36; | — |