Hypertension
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) aged between 40 to 70 years; (2) newly diagnosed as having stage one hypertension (SBP 140-159 and/or 90-99 mmHg) as defined by the seventh report of the Joint National Committee based on the results of blood pressure readings in two separate clinic visits; (3) currently not on any antihypertensive medications.
Exclusion criteria
Exclusion criteria: - Unwillingness or inability to modify current diet; - Alcoholic beverage intake > 14 drinks/week; - Use of food supplements that cannot be discontinued; - Current use of antihypertensive drugs or blood pressure-modifying medications that cannot be discontinued; - Cardiovascular disease event within the past 6 months; - Body mass index > 35 kg/m2; - Impaired fasting glucose or diabetes; - History of hypercalcemia or hyperkalemia; - Renal insufficiency; - Active malignancy or cancer therapy within the past 6 months; - Anemia; - Inflammatory bowel disease, malabsorption, hepatitis; - Asthma; - Gout; - Other chronic disease thought to interfere with the effect of the diet or with participation; - Use of antacids containing magnesium or calcium, insulin, oral corticosteroids, lithium, unstable doses of psychotropics, bile acid sequestering resins, oral antiasthmatics, digitalis, or phenytoin; - Dyslipidemia (Total cholesterol > 6.2 mmol/l, Triglyceride > 2.3 mmol/l, LDL-cholesterol: > 4.0 mmol/l); - Poor compliance during screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in BP and CV risk; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI and lipid profiles;Factors associated with non-optimisation of CV risk; | — |
Countries
China