bullous pemphigoid
Conditions
Interventions
Glucocorticoids group:This group receives systemic glucocorticoid, initially, with prednisone at 1mg/kg/day. Then we adjust the dose of glucocorticoid according to the patients' responses.
Sponsors
Institute of dermatology; Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Above 18 years old,male or female; 2. According with the diagnostic criteria for bullous pemphigoid(erythema and vesicles on skins and/or mucous membranes;dermatopathology shows subepidermal bulla; direct or indirect immunofluorescence (DIF/IIF) staining reveals IgG and/or C3 deposited as linear-pattern along the basement membrane zone; BP180 ELISA positive); 3. Clinical severity rating>1, the number of local vesicles<=10(scoring criteria refers to Appendix 13); 4. Subjects completely understand the trial and voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Regimen or dose of treatment for bullous pemphigoid have changed within one month; 2. Subjects who have severe local or systemic acute or chronic infection which is difficult to control and may affect the efficacy of the drugs or the clinical evaluation; 3. Subjects who have severe heart, lung, liver (ALT/AST=1.5×ULN), kidney or other severe diseases; 4. Pregnant and lactating female or subjects who have fertility plan recently; 5. With a history of malignant tumor; 6. Subjects who are allergic to the test drugs or have contraindications; 7. With other skin diseases that may affect the clinical evaluation; 8. Other conditions which researchers consider the subjects not compatible to the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pemphigoid antibodies titer;Glucocorticoid dosage;Date of glucocorticoid starting to reduce;Date of erosion surface completely drying; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood-routine;Urine-routine;Stool routine test;Urine pregnancy test;Electrocardiogram;Chest X-ray/CT;Pemphigoid antibodies titer; | — |
Countries
China
Contacts
Public ContactBAoxi Wang
Institute of dermatology; Chinese Academy of Medical Sciences
Outcome results
None listed