Generalized pustular psoriasis
Conditions
Interventions
TG treatment group:Take TG tablet 2 slices every time, thrice a day, the placebo of Acitretin Capsules 2 pills every time, twice a day
Acitretin treatment group:Take the placebo of TG tablet 2 slices every time, thrice a day, Acitretin Capsules 2 pills every time, twice a day
Sponsors
Institute of dermatology, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Males and females aged between 16 and 75 years; 2. Patients who was diagnosed as generalized pustular psoriasis; 3. Provide written informed consent; 4. Willing and able to comply with all aspects of the protocol.
Exclusion criteria
Exclusion criteria: 1. Localized pustular psoriasis; 2. patients who has allergy of Tripterygium Glycosides and Acitretin any ingredient; 3. Patients who used any of the following systemic treatments within 4 weeks before the Baseline visit eg: corticosteroids, immuno-suppressive drugs, biologics; 4. History of hepatitis B or hepatitis C, and advanced HIV infection; 5. Laboratory data such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and blood lipid profile was 1.5 times higher than the normal limits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of no new pustules and the old ones dried;Assessment for the pustule; | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin symptoms and laboratory data of comprehensive;The time of white blood cell and CRP turned to be normalized;Temperature;ESR;hs CRP; | — |
Countries
China
Contacts
Public ContactBaoxi Wang
Outcome results
None listed