Bullous pemphigoid
Conditions
Interventions
Glucocorticoids group:This group receives systemic glucocorticoid, initially, with prednisone at 1mg/kg/day. Then we adjust the dose of glucocorticoid according to the patients' responses
Sponsors
Institute of dermatology, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Above 18 years old,male or female; (2) According with the diagnostic criteria for bullous pemphigoid(erythema and vesicles on skins and/or mucous membranes;dermatopathology shows subepidermal bulla;direct or indirect immunofluorescence (DIF/IIF) staining reveals IgG and/or C3 deposited as linear-pattern along the basement membrane zone;BP180 ELISA positive); (3) Clinical severity rating>1(scoring criteria refers to Appendix 13); (4) Subjects completely understand the trial and voluntarily sign the informed consent
Exclusion criteria
Exclusion criteria: (1) Regimen or dose of treatment for bullous pemphigoid have changed within one month; (2) Subjects who have severe local or systemic acute or chronic infection which is difficult to control and may affect the efficacy of the drugs or the clinical evaluation; (3) Subjects who have severe heart, lung, liver (ALT/AST>=1.5×ULN), kidney or other severe diseases; (4) Pregnant and lactating female or subjects who have fertility plan recently; (5) With a history of malignant tumor; (6) Subjects who are allergic to the test drugs or have contraindications; (7) With other skin diseases that may affect the clinical evaluation; (8) Other conditions which researchers consider the subjects not compatible to the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pemphigoid antibodies titer;Date of stopping blisterring;Date of erosion surface completely drying; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glucocorticoid dosage;Electrocardiogram;Chest X-ray/CT; | — |
Countries
China
Contacts
Public ContactBaoxi Wang
Institute of dermatology, Chinese Academy of Medical Sciences
Outcome results
None listed