asthma
Conditions
Interventions
Asthma treatment group:Budisonide nasal spray and Budisonide/formoteral
Asthma control group:Placebo and Budisonide/formoteral
Sponsors
Guangzhou Institute of Respiratory Diseases
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. aged 18~60 mild-to-moderate simple asthma; 2. after nasal examination (nasal lavage counting EOS>2.58/*200) was included in the research; 3. determination of pulmonary function FEV1 %Pred (forced expiratory volume in 1 second of expected value percentage)70% or higher; 4. X-ray films has no obvious abnormalities; 5. Participants must be willing to participate in the study and to comply with the requirements of the study, understand and observe and comply with the corresponding inspection, comply with the dosage plan, follow-up, and voluntarily signing a written informed consent.
Exclusion criteria
Exclusion criteria: 1. associated with COPD, interstitial pneumonia, other types of chronic respiratory system disease etc; with other serious systematic disease (such as cardiovascular, metabolic, immune, neural, urinary and blood, etc.); 2. has a history of the nasal tumors, trauma, nasal septum deviation obviously, specialist sinusitis, allergic rhinitis has been diagnosed; 3. upper or lower respiratory tract infection within recent four weeks; 4. the body temperature is more than 37.5 ? or abnormal blood test(white blood cell count > 10x10*9/L or <4x10*9/L); 5. history of drug abuse, alcohol abuse or anesthesia or with a history of mental illness and against personality, motivation, suspicious, or other emotional or mental issues that may affect participation in the study; 6. smoking patients (or smoking cessation less than four weeks); 7. during pregnancy, lactation women; 8. taking part in other drug clinical trial project; 9. can not cooperate with related inspection or for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eosinophil in nasal lavage;Eosinophil in induced sputum;FeNO;branchial provocation test;Histamine nasal provocation test;Skin prick test;Eosinophil count in blood;Total IgE in serum; | — |
Countries
China
Contacts
Public ContactZhong Nanshan
Outcome results
None listed