prophylaxis and treatment of endoscopic injection of BTX-A to treat esophageal strictures after endoscopic submucosal dissection(ESD)

rophylaxis and treatment of endoscopic injection of BTX-A to treat esophageal strictures after endoscopic submucosal dissection

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-12003188

Enrollment

Unknown

Registered

2012-02-03

Start date

2012-06-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal strictures after endoscopic submucosal dissection

Interventions

BTX-A group:s) BTX-A group:endoscopic injection of BTX-A

Control:Routine treatment

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: from June 2012 to January 2014; Mucosal defects over one-seconds of esophageal cirumference by ESD for esophageal mucosal lesions; Agreed to participate in the study and signed an informed consent.

Exclusion criteria

Exclusion criteria: Tumor recurrence; Tracheoesophageal fistula; Endoscopic dilation, stent placement, incision endoscopic treatment in the past; Abnormal esophageal congenital anatomical structure; Esophageal varices; Reflux esophagitis(LA C-D); History of botulinum toxin poisoning, allergies or history of treatment; endoscopy contraindications

Design outcomes

Primary

Measure	Time frame
symptom scores of dysphagia;esophageal diameter;collagen type I and III contents;TGF-ß1 mRNA expression and protein level;histopathology;hydroxyprolin;	—

Countries

China

Contacts

Public ContactQingsen Liu

liuqingsen301@163.com+86 010 55499015

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 13, 2026