Chronic heart failure
Conditions
Interventions
Group A:Shenmai injection + basical treatment
Group B:Placebo+basical treatment
Sponsors
First Affiliated Hospital of Guangzhou University of chinese medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic crateria of chronic heart failure, NYHA cardiac function Grade II-IV; 2. Meet the TCM differentiation criteria of symptoms and signs of "Qiyin liangxu Zheng"; 3. prior standard medicin treatment as outpatient for more than 1 months and condition was not well uncontrolled that need inpatient treatment; 4. Male or female patients aged 40-80 years; 5. patient were well informed and voluntarily given the witten informed consent.
Exclusion criteria
Exclusion criteria: 1. acute cardiac dysfunction; 2. heart failure caused by reasons other than coronary artery disease; 3. combined with cardiac shock, or fetal arhythmia, degree II type II or severer atrioventricular block(AVB), obstructive cardiomyopathy, unrepaired valvular heart disease,Constrictive pericardis, cardiac tamponade;pulmonary embolism; acute myocardial infarction; heart failure combined with uncontrolled infection (eligible when the infection was controlled and otherwise eligible), and other diseases which may confuse the evaluation of the efficacy and the saftey of the heart failure. 4. Symptoms get worse caused by digitalis toxication; 5. Patients with Serious liver, kidney disease, or hematopoietic system disease, LFT( ALT, AST) >80 u/L, renal disfunction, or psychosis mental disease patient; 6. Pregnancy or breast-feeding women; 7. Patients with severe diabetes; 8. Prior take part in other clinical studies in 1 month; 9. Known Allergic to the trial medicine; 10. Other conditions that the investigor thought should not participate the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6 minites walking test;NYHA cardiac functional classification;TCM systoms and signs index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lee's pathological grade;SF-36 Health Survey Scales;Brain natriuretic peptide (BNP);Echocardiograph; | — |
Countries
China
Contacts
Public ContactShaoxiang Xian
Outcome results
None listed