Renal Transplantation
Conditions
Interventions
transfer group:transfer tacrolimus to SRL
control:continue use tacrolimus
Sponsors
Kidney Disease Center, The First Affiliated Hospital of Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. ESRD patients who are scheduled to receive renal transplant from DCD donor, a living unrelated donor, or a living related but mismatched(excluding zero antigen mismatched) donor; 3. Preoperative PRA<=10%; 4. Renal transplant-native patients; 5. Women of childbearing potential must have a negative serum pregnancy test before receiving treatment with SRL.Women of childbearing potential or men with sexual partners of childbearing potential should use medically acceptable contraception from study treatment initiation until at least 3 months after the last dose of SRL; 6. Patients who are willing to provide informed consent.
Exclusion criteria
Exclusion criteria: 1. Signs of systemic or local active major infections; 2. Signs of infiltration,cavity or consolidation on chest X-ray; 3. Recipients diagnosed with primary disease such as focal segmental glomerulosclerosis(FSGS)or membrane proliferaive glomerulonephritis(MPGN); 4. Patients who are scheduled to receive multi-organ transplants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GFR of graft; | — |
Contacts
Public ContactChen Jianghua
Outcome results
None listed