HBeAg Negative Chronic Hepatitis B Patients
Conditions
Interventions
standard therapy group:pegylated interferon alfaa-2a
extended therapy group:pegylated interferon alfaa-2a
Sponsors
Guangdong General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. patients with HBeAg negative chronic hepatitis B from 18 to 65 years old; 2. patients with antivirus therapy first time; 3. Incluslon criteria were treatment-naive HBeAg-negative CHB with ALT>=2*ULN and 2000IU/mL<=HBV DNA<=200000IU/mL.
Exclusion criteria
Exclusion criteria: 1. patients with known hypersensitivity to alpha interferons, to E. coli-derived products, to polyethyleneglycol or to any component of the product; 2. patients with autoimmune disease; 3. patients with decompensated cirrhosis; 4. HIV-HCV patients with cirrhosis and a Child-Pugh score>5; 5. patients with HAV, HCV, HDV and/or HIV; 6. pregnant woman; 7. patients with baseline neutrophil counts <1500 cells/mm3, with baseline platelet count <90,000/mm3 or baseline hemoglobin <12 g/dL; 8. Patients with psychiatric illness; 9. Patients with retinopathy including retinal hemorrhages, cotton wool spots, papilledema, optic neuropathy, and retinal artery or vein obstruction; 10. patients with endocrine disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBsAg suppression rate; | — |
Countries
China
Contacts
Public ContactChen Xiaoping
Outcome results
None listed