gastric cancer
Conditions
Interventions
group of concurrent chemoradiotherapy:concurrent chemoradiotherapy
Group of chemotherapy:chemoradiotherapy
Sponsors
Department of medical oncology, Cancer Center, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age from 18-75y; 2. Patient with postoperative gastric cancer and which was confirmed by positive pathological diagnosis; 3. R0 and D2 Radical Gastrectomy with organ preserved should be delivered (with organs reserves) (the numbers of dissected lymph nodes should be more than 15); 4. Within 3 mothes after operation; 5. Post-surgery stage >=T4a, N0-3, M0 according to 2010 edition UICC/AJCC staging; 6. ECOG: 0-1; 7. No radiotherapy or systematic chemotherapy was delivered before or after operation; 8.Function of main organs are normal: (1) The results of blood tests are normal (HB>=9g/l, N >=1.5*10^9/L, PLT>=100*10^9/l); (2) The results of Blood Biochemistry are normal: Crea, TB <=1.0 folders; ALT, AST<=2.5 folders; 9. Women of reproductive age must take pregnancy test (serum or urine)in the first seven days, and the result should be negative, and they should be willing to use appropriate methods for contraception during the trials and eight weeks after the treatment. Men should adopt operation sterilization or agree to use appropriate methods for contraception during the trials and eight weeks after the treatment; 10. Patients with good compliance and follow-up should participate in the trial voluntarily and should sign the informed agreement.
Exclusion criteria
Exclusion criteria: 1. Patient who has had the malignant tumor at present or before, except for cured basal cell carcinoma of skin or Cervical carcinoma in situ; 2. Pregnant or lactation women; 3. Serious heart disease, uncontrolled Diabetic; 4. psycologic disease; 5. Seriously or uncontrolled infection; 6. Allergy to S-1 or oxaliplatin; 7. Participant in another trial in the initial 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3y-disese free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| 3y-overall survival;local control rate; | — |
Countries
China
Contacts
Public ContactBi Feng
Outcome results
None listed