Neurologic impairment in patients with acute cerebral infarction
Conditions
Interventions
experimental group:Huatou Zaizao Pills
control group:Placebo
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patient must be between the ages of 18 and 70 years; 2. Patient must be with ischemic stroke and at stroke onset 14th day; 3. Patient must be with mRS score=7; 7. Only patient with an anterior circulatin infarction of Oxfordshire Community Stroke Project (OCSP)classification and atherothrombosis or cardioembolism of modified TOAST classification were accepted; 8. Patient must understand and be willing,able and likely to comply with all study requirements; 9. Informed consent must be obtained.
Exclusion criteria
Exclusion criteria: 1. Patient with severe cognitive impairment who not be able to give voluntary written informed consent or participate in this study; 2. Maybe not to comply with all study requirements or not be able to participate in this study for regional or social reasons; 3. Pregnancy,breast feeding and the possible pregnancy during study; 4. Participating in another medicine or interference study in the same or at least within 3 months,or enrolled in this study in other location; 5. Patient with mRS>= at enrollment; 6. Coma patient with GCS=2; 9. Lacunar infarction; 10. Patient accompanied with systemic diseases:gastrointestinal hemorrhage,advanced carcinoma, liver malfunction,kidney malfunction,severe dementia or mental disorder; 11. Unstable patient after receiving thrombolytic therapy; 12. Cerebral hemorrhage verified by CT or MRI; 13. History of major operation or trauma within 6 weeks or having a major operation arrangement; 14. Allergic to one or more components of study medicine; 15. Receiving study medicine or components of study medicine within 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients with a modified Rankin Scale (mRS) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of patients with a mRS score;NIHSS (National Institute of Health Stroke Scale);The proportion of patients with BI;MMSE(Mini-Mental State Examination)score;recurrence rate;mortality; | — |
Contacts
Public ContactQiang Dong
Outcome results
None listed