Chronic obstructive pulmonary disease complicated with chronic pulmonary heart disease (both Qi and Yin deficiency)
Conditions
Interventions
Experimental:Shenmai injection 60ml with 5% glucose injection 250ml intravenous infusion a day for 10 days
control:5% glucose injection 60ml with 5% glucose injection 250ml intravenous infusion a day for 10 days
Sponsors
Chengdu University of TCM Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. To be diagnozed as Chronic obstructive pulmonary disease complicated with chronic pulmonary heart disease (Qi and Yin deficiency); 2. Aged 35~70 years; 3. Heart function I~III grade; 4. Signed the informed consent according to the GCP principle.
Exclusion criteria
Exclusion criteria: 1. Tem. >=38.0 degree C; 2. Heart function deficiency caused by other reason; 3. Complicated with diabetes mellitus, hypertension (high risk, high risk), severe arrhythmia; 4. Onset myocardial infarction or acute coronary syndrome in past three months; 5. Patient with respiratory insufficiency needs invasive mechanical ventilation; 6. Patient complicated with cardiac neurosis, psychosis, depression; 7. Patient complicated with other severe organic liver, or kidney, or blood system
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of the symptoms include short breath, palpitations, dry mouth;Change of the both Qi Yin deficiency zheng;COPD CAT score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of FEVlFEVl, FEVl/FVCFEVl/FVC;The whole blood viscosity (high, low shear), plasma viscosity, erythrocyte rheological properties, plasma;eart function by NYHA grade;Pulmonary artery pressure (by echocardiography); | — |
Countries
China
Contacts
Public ContactDuan Junguo
Outcome results
None listed