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Translational study of the molecular anti-injury mechanism and clinical regulatory pathway of lactobacillus minor integral membrane protein on intestinal epithelium through inhibition of zonulin regulated by microRNA-122a

Translational study of the molecular anti-injury mechanism and clinical regulatory pathway of lactobacillus minor integral membrane protein on intestinal epithelium through inhibition of zonulin regulated by microRNA-122a

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-12002841
Enrollment
Unknown
Registered
2012-12-09
Start date
2012-12-16
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dysfunction of intestinal barrier

Interventions

Control:Perioperative use of Placebo
Probiotics:Perioperative use of Probiotics
MIMP:Perioperative use of MIMP

Sponsors

the Sixth Affiliated Hospital of Sun Yat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age between 25 and 75 years; 2. Biopsy and histological comfirmation; 3. Radical resection; 4. No distant metastasis.

Exclusion criteria

Exclusion criteria: 1. patient was pregnant; 2. known lactose intolerance; 3. clinically significant immunodeficiency; 4. additional gastrointestinal disorders; 5. received antibiotics during the 10 days before surgery; 6. evidence of infection; 7. Other pre, probiotic or excessive fiber intake within 2 weeks of surgery; 8. emergency operation; 9. the patient had a distant metastasis.

Design outcomes

Primary

MeasureTime frame
Blood D-lactate;I-FABP;Zonulin protein;Permeablility;Tight junction protein;—

Countries

China

Contacts

Public ContactZhi-Hua Liu
liuzhh26@mail.sysu.edu.cn+86 13826188969

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026