de adaptation to high altitude disease
Conditions
Interventions
1:sildenafil
2:Placebo
Sponsors
PLA Respiratory Institute of Internal Medicine, Xinqiao Hospital, The 3rd Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~60 years; 2. Both gender; 3. Generations living in the low elevation area; 4. Adaptation to high altitude environment in a short term living (less than 1 year); 5. To be diagnosed as the de adaptation to high altitude disease after back to the low elevation area, the symptom is graded as slight, moderate, the sympotm scores at the range of 6~25; 6. Signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Attended other trials or addministrated other study drug whithin four weeks before this study; 2. Suffered acute high altitude disease during lived in high altitude, and returned to low altitude area for treating high altitude pulmonary edema or/and brain edema; 3. With history of orginal organic diseases on heart, kidney, brain, lung; 4. With tumour; 5. With blood system diseases; 6. Brain disorder caused judgement unnormal; 7. To be backed to low elevation area due to not adoptation when shortly stay in high altitude; 8. Stay in high altitude longer than one year; 9. Suffered high altitude cardio disease and polycythemia when stay in high altitude; 10. To be with influenza, upper respiratory infection, infectious diarrhea after return back to low elevation area; 11. Drugs and / or alcohol abuse; 12. Unwilling to submit to test arrangement or automatically withdraw from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mPA; | — |
Secondary
| Measure | Time frame |
|---|---|
| HR;LVEF;LVFS;Pulmonary artery diameter;Three tricuspid valve diastolic blood flow spectrum;de adaptation to high altitude disease score;CK;CK-MB;LDH;ET-1;NO; | — |
Countries
China
Contacts
Public ContactWang Guansong
Outcome results
None listed