ESCC
Conditions
Interventions
A:Preoperation Neoadjuvant
B:Post operation Neoadjuvant
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Tumour histologically documented squamous cell carcinoma of the thoracic esophagus must be resectable;The pre-treatment clinical stage must be T3-4N0-1M0 or T1-2N1M0; 2. No anti-tumor therapy received; 3. Estimated survival time more than six months; 4. Aged 18 to 65 years old; 5. WBC>=4.0*10^9/l, ANC>=1.5*10^9/l, PLT>=100.0*10^9/l, Hb>=90g/l; hepatorenal function is normal; 6. KPS>80; 7. The patient can understand the research and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Already received anti-tumor therapy (including chemotherapy,radiotherapy,surgery); 2. Known or suspected allergy to chemotherapy drug like taxol,carboplatin,etc; 3. Already existed or merged with hemorrhagic disease; 4. Female patients in pregnancy or lactating; 5. Without informed consent due to psychology, family, community, etc; 6. Can't use the stomach for replacing esophagus due to previous surgery; 7. Patients with peripheral neuropathy, CTC grade>=2; 8. With a history of other malignancies before enrollment, except for non-melanoma skin cancer, in situ cervical cancer; 9. Researchers consider the patient unsuitable to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS;QOL; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;Safety of Treatment; | — |
Countries
China
Contacts
Public ContactMao Weiming
Outcome results
None listed