myocardial infarction
Conditions
Interventions
Two groups:perindopril vs no treatment
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
42 Years to 82 Years
Inclusion criteria
Inclusion criteria: participants with T2DM which diagnosed as glycated hemoglobin>=6.1 mmol/L and controlled by diet or blood glucose lowing agents were recruited. All patients were in accordance with the diagnostic criteria for AMI and received acute percutaneous coronary intervention (PCI) within 12h after onset of symptoms and followed a similar anticoagulation and medication (beta blocker, statin) regimen according to established guidelines. The criteria for AMI are as follows: 1. typical ischemic chest pain lasting for>=30min; 2. ECG changes represent as new onset ST-segment elevation >=0.1 mV in 2 or more contiguous peripheral leads, and/or >=0.2 mV in 2 or more contiguous precordial leads; 3. Evidences of myocardial injury or necrosis indicated by elevated serum cardiac biomarker including creatine kinase (CK) and/or troponin T (TnT).
Exclusion criteria
Exclusion criteria: exclusion criteria were uncontrolled hypertension or blood pressure<=100/70mmHg, using ACE inhibitors/ARB in a week or contradicting ACE inhibitors therapy, severe arrhythmia, IV level cardiac function or EF<=35%, history of renal or hepatic disorders and having other infarction disease such as pulmonary or cerebral infarction in recent days (6 months)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| endothelial progenitor cell;echocardiograph; | — |
Secondary
| Measure | Time frame |
|---|---|
| VEGF;hsCRP; | — |
Countries
China
Contacts
Public ContactXu Biao
Outcome results
None listed