atopic dermatitis
Conditions
Interventions
test group:Lidocaine Hydrochloride Injection
control group:sodium chloride solution
Sponsors
The First Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) The age of 14 to 65 years old, male or female; (2) according to Hanifin and Rajka diagnostic criteria for diagnosis of atopic dermatitis; (3) SCORAD objective score 40 points or more, severe atopic dermatitis; (4) researchers overall score (IGA) >=4 points; (5) conventional therapy (topical strong effect of glucocorticoid hormones or immune regulation, etc.) can not effectively control the disease; (6) stable vital signs; (7) have signed informed consent.
Exclusion criteria
Exclusion criteria: (1) those who are allergic to lidocaine or other local anesthetics; (2) abnormal liver and kidney function: AST, ALT, or serum creatinine values greater than the upper limit of normal; (3) severe heart disease (such as atrioventricular block or severe bradycardia); (4) history of epilepsy; (5) phototherapy, systemic sugar corticosteroids or immunosuppressants (such as cyclosporine, azathioprine, or immunoglobulin) treatment within 3 months, and at the same time, participate in other clinical researchers; (6) malignancy or other chronic infected person; (7) the subjects to be judged unbeleivable or will be poor comliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scoring Atopic Dermatitis;Investigator’s global assessement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical evaluation of patients;Dermatology Life Quality Index; | — |
Countries
China
Contacts
Public ContactXing-hua Gao
Outcome results
None listed