Severe hepatitis B (liver failure)
Conditions
Interventions
Comprehensive treatment:Antiviral and other drugs
Artificial liver support:Comprehensive treatment and Artificial liver support
Liver transplantation:Comprehensive treatment and Liver transplantation
Aritificial liver support+transplantation:Comprehensive treatment and Liver transplantation
Sponsors
The FIrst Affiliated Hospital, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients are informed with written consents; 2. Male or female aging from 18-65 years old; 3. HBsAg positive;D. With prior history of chronic liver disease, quick devlopement of gastrointestinal symptoms, such as extreme fatigue, profound loss of appetite, abdominal distention, nausea andvomitting; 4. Significant hemorrhagic tendency, PTA=17.1umol/L.
Exclusion criteria
Exclusion criteria: 1. Acute fatty liver of pregnance; 2. Drug-induced liver injury; 3. Alcoholic liver disease (daily alcohol intake >=20g in female and>=40g in male,); 4. Autoimmune liver disease; 5. Congenital metabolic liver disease, eg. Wilsons disease, hemachromatosis; 6. HBV relapsers post-liver transplantation; 7. Coinfection with other viruses, any of the antibodies positive: anti-HAV IgM, anti-HCV, anti-HEV IgM, anti-CMV IgM, anti-EBV IgM andanti-HIV; 8. Severe comorbidities with clinical significance, including uncontrolled cardiac, pulmonary, nephritic, digestive, nerve or psychiastric, auto-immune, metabolic andmaglinant diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TB;Cr;INR;HBV-DNA; | — |
Countries
China
Contacts
Public ContactJian-Rong Huang
Outcome results
None listed