sepsis
Conditions
Interventions
A:low dose heparin pumping continuously
B:No heparin pumping
Sponsors
Binzhou Medical University
Eligibility
Sex/Gender
All
Age
17 Years to 45 Years
Inclusion criteria
Inclusion criteria: According to the diagnostic criteria for sepsis on American Thoracic Society in 1992 (American College of Chest Physicians / Society of Critical Care Medicine, ACCP / SCCM) and the pre-DIC diagnostic criteria established on the seventh country thrombosis and Bleeding meeting in 1999.
Exclusion criteria
Exclusion criteria: thrombotic disease; patients who need the blood or peritoneal dialysis for the chronic renal failure; patients with severe chronic lung, kidney, or liver diseases; patients with contraindications of using heparin like congenital bleeding disorders or bleeding tendencies; patients with a history of serious head injury, intracranial surgery or stroke within 28 days of enrollment in the study; patients with a brain arteriovenous malformation, cerebral aneurysm or a history of extensive damage on central nervous system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prothrombin fragment 1+2;Thrombin-antithrombin complex;Antithrombin-?;Plasminogen activator inhibitor-1; | — |
Secondary
| Measure | Time frame |
|---|---|
| APACHE-II score;Mechanical ventilation time;number of days staying in ICU;28-day mortality; | — |
Countries
China
Contacts
Public ContactChang-jun LV
Outcome results
None listed