Postoperative cognitive dysfunction
Conditions
Interventions
1:Intravenous administration of ulinastatin after induction of anesthesia
2:Intravenous administration of etanercept after induction of anesthesia
3:Intravenous administration of Dexmedetomidine during induction and maintenance of anesthesia
4:Intravenous administration of placebo
Sponsors
Affiliated Drum Tower Hospital of Medical School of Nanjing University
Eligibility
Sex/Gender
All
Age
12 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-II older than 65 years patients for elective vascular surgery; 2. ASA I-II, aged 10-18 years adolescent patients for elective scoliosis surgery.
Exclusion criteria
Exclusion criteria: Old patients exclusion criteria: 1. Serious trachea dysfunction; 2. Cerebral infarction or hemorrhage in the near future; 3. Mental illness, and can not be effectively communicate with the psychiatrist; 4. Drug dependence or alcohol abuse; 5. Illiteracy, Preoperative Mini Mental State (MMSE) score <23 points. adolescent patients exclusion criteria: 1. Serious congenital disease; 2. Serious liver and kidney dysfunction; 3. Central nervous system diseases and mental illness; 4. Serious auditory or visual disorder; 5. Preoperative Mini Mental State (MMSE) score <23 points.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hemodynamics index;adnephrine;norepinephrine;glucocorticoid;ß-endorphin;interleukin-6;interleukin-1;tumor necrosis factor, TNF;C reactive protein, CRP;interleukin-10;beta 100;neuronspecific enolase;mini-mental state examination, MMSE;Visual verbal learning test;Digit Symbol Test, DST;Number Connection Test, NCT;Digital span test, DST;stroop colour-word test, SCW; | — |
Countries
China
Contacts
Public ContactXiaoping Gu
Outcome results
None listed