The analgesia and sedation for mechanisme ventilation
Conditions
Interventions
the group of sulfentanil:intravenous infusion with sulfentanil
the group of fentanyl:intravenous infusion with sulfentanil
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. the patients receiving mechanical ventilation requires sedation in ICU; 2. The expected duration of mechanical ventilation longer than 24H; 3. aged 18 to 80 years; 4. agreed to participate in the study, and informed consent.
Exclusion criteria
Exclusion criteria: 1. allergic to opioid 2. patients with shock: MBP 3 months); 7. alcohol or drug dependent patients; 8. patients with neuromuscular diseases; 9. disturbance of consciousness (trau matic brain injury, stroke, intracranial infection, dementia, etc.); 10. liver dysfunction: ALT or AST> normal 5 times; 11. body mass index BMI (weight kg/height m2) is not 18 to 30; 12. patients with organic heart disease preopertation (such as sick sinus syndrome, atrioventricular block, etc.); 13. severe dehydration, electrolyte imbalance; 14. with severe renal dysfunction and severe disturbance water and salt metabolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score;Sedation score;The amount of analgesic drugs;Frequency of incresing sedative drugs;The amount of sedative drugs;heart rate;blood pressure;oxygen saturation;respiration rat; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mecanical ventilation;serum cortisol leve; | — |
Countries
China
Contacts
Public ContactDu Zhaohui
Outcome results
None listed