Chronic Subdural Hematoma
Conditions
Interventions
A1:Oral atorvastatin regimen continued
A2:Patients were done drilling hematoma drainage when
A3:Postoperative large rehydration treatment
A4:Moderate drop cranial pressure treatment according
P1:Oral placebo
P2:Patients were done drilling hematoma drainage when accord with the standard of operation
P3:Postoperative large rehydration treatment
P4:Moderate drop cranial pressure treatment according to patients condition
Sponsors
Tianjin medical university general hospital
Eligibility
Sex/Gender
All
Age
45 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. age > 45 years old, male or female; 2. chronic subdural hematoma is located in the upward transtentorial cerebellum; 3. liver function have no obvious abnormity; 4. Should the surgery, the researchers judge whether accord with neural surgical indications; 5. Should the surgery, preoperative Hb, PLT, PT, INR and APTT reach surgical indications; 6. patients have fully understand the the study, voluntary take the test and informed agreement signed.
Exclusion criteria
Exclusion criteria: 1. patients who have known allergy and allergic constitution on this study drug ingredients; 2. hematoma is caused by tumor, and hematologic diseases; 3. hepatitis and liver disease not get controlled, and other diseases or assessment the researchers think that may interfere with in the study; 4. have taken part in other drugs research in nearly four weeks; 5. not take the drilling drainage, and in the perioperative using hemostatic agents or (and) other drugs in hematoma cavity, postoperative drainage less than 24 hours or not drainage enough, and postoperative infections occurred; 6. Definite diagnosis in patients with chronic subdural effusion, the symptoms and signs are stable six months or more; 7. compliance is bad, the research for the researcher can not be complete; 8. for any reason, the researchers think any not suitable for the situation was.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the quantity change on CT before and after treatment;Huge hematoma group main observation preoperative; | — |
Secondary
| Measure | Time frame |
|---|---|
| the symptoms improve before and after every stage;Blood routine before and after every stage treatment;Liver function before and after every stage treatment;Blood coagulation function;GOS prognostic score;Daily life ability score (ADL score); | — |
Countries
China
Contacts
Public ContactJianning Zhang
Outcome results
None listed