Clinical assessment of hydroxyethyl starch (130/0.4) pretreatment on perioperative lung protection in liver transplantation patients

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-12002311

Enrollment

Unknown

Registered

2012-06-25

Start date

2012-07-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung injury

Interventions

hydroxyethyl starch:infuse hydroxyethyl starch 20ml/kg before anhepatic phase

succinylated gelatine:infuse succinylate gelatine 20ml/kg before anhepatic phase

saline:infuse saline 20ml/kg before anhepatic phase

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Late-stage liver disease patients; 2. Plan for orthotopic liver transplantation;3. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Oxygenation index (PaO2/FiO2)<300mmHg or severe respiratory disease such as hepatopulmonary syndrome before operation; 2. Hepatic tumor; 3. Severe cardiac malfunction before operation; 4. Severe pulmonary edema; 5. Severe kidney malfunction; 6. Intracranial hemorrhage; 7. Allegic to hydroxyethyl starch or human albumin.

Design outcomes

Primary

Measure	Time frame
incidence of acute lung injur;	—

Secondary

Measure	Time frame
survival rate after operation;	—

Countries

China

Contacts

Public ContactWang Xiangrui

xiangruiwang@gmail.com+86 13701901953

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026