Changes of fMRI and EEG stimulating-reaction of patients in vegetative state or minimal consciousness state after treating by amantadine or levodopa

amantadine or levodopa treat patients in vegetative state or minimal consciousness state: a randomized, open-label trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-12002299

Enrollment

Unknown

Registered

2012-06-24

Start date

2012-07-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients in vegetative state or minimal consciousness state

Interventions

A:amantadine

B:levodopa

C:No treatment

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. 18 years <= Age <=65 years; 2. in vegetative state or minimal consciousness state (5<= CRS-R <=14) at least for 4 weeks.

Exclusion criteria

Exclusion criteria: 1. instability of vital signs; 2. pregnancy; 3. serious renal disease (estimated creatinine clearance less than 60 ml per minute); 4. more than one seizure in the previous month prior treatment; 5. prior treatment with amantadine or levodopa, and allergy to amantadine or levodopa; 6. poor compliance; 7. receiving a psychoactive medication at the time of enrollment.

Design outcomes

Primary

Measure	Time frame
fMRI(BOLD);EEG stimulating-reactio;	—

Secondary

Measure	Time frame
Coma Recovery Scale-Revised (CRS-R);	—

Countries

China

Contacts

Public ContactWen Jiang

Jiangwen@fmmu.edu.cn+86 13991905538

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026