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Antiarrhythmic drug therapy for patients with idiopathic outflow tract premature ventricular contractions

Antiarrhythmic drug therapy for patients with idiopathic outflow tract premature ventricular contractions

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-12002298
Enrollment
Unknown
Registered
2012-06-25
Start date
2012-08-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

idiopathic outflow tract premature ventricular contractions

Interventions

Control group:placebo
propafenone:propafenone

Sponsors

the First Affiliated Hospital, Nanjing Medical University, Jiangsu Province People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. age 18~65 years, for both gender; 2. Diagnosised as outflow tract ventricular premature beats by ECG; 3. Holter examination showed the the premature ventricular cnotractions burden were more than 5% but less than 15%.

Exclusion criteria

Exclusion criteria: 1. pathients wiht malignant tumor or other serious illnesses, and the life expectancy <1 year; 2. pathients wiht structural heart disease (including coronary heart disease, heart failure, cardiomyopathy, myocarditis, congenital heart disease, valvular heart disease) or heart ultrasound abnormal; 3. HR <60 beats / min; 4. Blood pressure less than 100/60mmHg; 5. sustained ventricular tachycardia; 6. the outflow tract ventricular arrhythmia caused by reversible reasons (electrolyte imbalance, drugs, poisoning and infection, etc.) ; 7. Syncope or threatened syncope symptoms.; 8. Patinets accompanied by slow arrhythmia or can not tolerate anti-arrhythmic drug therapy in patients with; 9. Patinets accompanied by a variety of types of ventricular arrhythmia; 10. pregnant or lactating women; 11. incapacity or loss of part of the incapacitated person; 12. cognitive impairment, dementia, severe psychiatric patients; 13. Patinets with significantly abnormal liver and kidney function and other serious uncontrolled systemic diseases (such as blood system diseases).

Design outcomes

Primary

MeasureTime frame
Premature ventricular contractions the number of 24-hour ambulatory ECG;SF-36 tabel for quality of life;LVEF and LVED;

Secondary

MeasureTime frame
NT-proBN;

Countries

China

Contacts

Public ContactKejiang Cao
nydxzk@163.com+86 25 68135273

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026