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Research of the mechanisms of oropharyneal care combined with duodenum flushing on preventing ERCP-related cholangitis

Research of the mechanisms of oropharyneal care combined with duodenum flushing on preventing ERCP-related cholangitis in biliary obstruction patients: a perspective randomized study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-12002284
Enrollment
Unknown
Registered
2012-06-13
Start date
2012-06-20
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ERCP-related cholangitis

Interventions

Control group:None
Saline group:Oropharyngeal care combined with duodenum flushing
Amikacin group:Oropharyngeal care combined with duodenum flushing with amikacine

Sponsors

Department of Endoscopy, Eastern Hepatobiliary Hospital, Second Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Total bilirubin elevations before ERCP were more than 2 times the upper limit of normal(>34.2umol/L); 2. Body temperature<=37.5 degree C; 3. WBC count was normal (4.0-10.0*10^9/L); 4. Bile duct obstruction was diagnosed by ultrasound/CT/MRCP.

Exclusion criteria

Exclusion criteria: 1. Total bilirubin elevations before ERCP were less than 2 times the upper limit of normal (5.1-34.2.1µmol/L); 2. Body temperature>37.5 degree C; 3. WBC count>10.0*10^9/L; 4. Antibiotics were administered before ERCP; 5. Previous biliary intervention (PTC, EST, EPBD and stenting); 6. Surgically altered anatomy; 7. ERCP contraindication.

Design outcomes

Primary

MeasureTime frame
ERCP-related cholangitis;The positive rate of bacterial culture of main papilla;The positive rate of bacterial culture of bile at the beginning and end of ERCP;bleeding;—

Secondary

MeasureTime frame
Post ERCP pancreatitis;Procedure related motility;—

Countries

China

Contacts

Public ContactShuping WANG
wangshp415@126.com+86 21 81875224

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026