Diabetes
Conditions
Interventions
Group A:sitagliptin monotherapy
Group B:Acarbose monotherapy
Sponsors
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Sign the written informed consent before the study; 2. Aged 18 to 75; 3. Patients with type 2 diabetes (ADA criteria, 2010); 4. BMI between 19kg/m2 to 43/kg/m2; 5. HbA1c 6.5% to 10.0%; 6. Without use of any kind of anti-diabetic drugs in 8 weeks.
Exclusion criteria
Exclusion criteria: 1. Without sufficient ability to communicate and to fulfill the study; 2. Type 1 diabetes or other special kinds of diabetes; 3. Severe infection, cancer, stressful situation includes trauma, surgery; 4. Patients with any other kinds of endocrine diseases,with any autoimmune disease or connective tissue disease; 5. Patients in gestation period, lactation period or want to have prengancy in study period; 6. Random blood glucose level >=14.4mmol/L in inclusion period; 7. Allergic to active pharmaceutical ingredients; 8. Abnormal liver function (Transaminase higher than 2.5 times the upper limit of normal) and abnormal renal function(blood Scr >50µmol/L) ; 9)Severe systemic disease ; 10)Acute ,chronic pancreatitis or pancreatectomy history; 11)Use of any kind of drugs which can affect study, includes corticosteroid,immunosuppressive agents; 12) Patients with mental disorder; addictive to any kinds of drug ,Smokers or alcohol abuser; 13)Participates in other trials within 3 months; 14)Patients that researchers regard not eligible for inclusion.;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose;Ghrelin;Insulin;Glucago; | — |
Countries
China
Contacts
Public ContactYaoming Xue
Outcome results
None listed