IgA Nephropathy
Conditions
Interventions
Treatment group:IgA nephropathy side (granules)+TWP tablet
Control group:Chinese medicine simulation granules + The Tripterygium simulation piece
Sponsors
Hangzhou Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. person has signed the informed consent; 2. aged 16 to 65 years; 3. The renal biopsy diagnosed as IgA nephropathy and excluded patients with secondary renal; 4. 24h urinary protein >=0.5g; GFR (MDRD formula) >=30ml/min; 5. selected for the first 2 weeks of not using hormones or immunosuppressive therapy.
Exclusion criteria
Exclusion criteria: 1. secondary IgA nephropathy; 2. pregnancy or pregnant and lactating women; 3. combined determination, brain, lung, liver, hematopoietic system, diabetes and other serious primary disease, or cancer, active tuberculosis in patients with wasting disease; 4. nearly two weeks, glucocorticoids, immunosuppressive therapy; 5. mental illness; 6. allergy against the drugs; 7. those who participate in other clinical drug trials; 8.examinations showed HBeAg or hepatitis B HBV-DNA> 103 copies/L; 9.To be not belong to Wind-dampness syndromes within the interference.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| renal pathology;Changes of TCM clinical syndrome score before and after treatment;GFR;proteinuria(Upro);urine erythrocyte;Serum creatinine;Serum albumin;Alanine aminotransferase, ALT;Urinary podocytes;Interleukin-6, IL-6;Tumor necrosis factor-alpha (TNF-alpha);Transforming growth factor-beta 1 (TGF-beta 1); | — |
Countries
China
Contacts
Public ContactCHEN Hongyu
Outcome results
None listed