the use of drugs in the maintence of general anesthesia
Conditions
Interventions
group 1:propofol+ketamine 0mg/kg/h+remifentanyl0.1ug/kg/h for maintence of general anesthesia
group 2:propofol+ketamine 0.5mg/kg/h+remifentanyl0.1ug/kg/h for maintence of general anesthesia
group 3:propofol+ketamine 1mg/kg/h+remifentanyl0.1ug/kg/h for maintence of general anesthesia
group 4:propofol+ketamine 1.5mg/kg/h+remifentanyl0.1ug/kg/h for maintence of general anesthesia
group 5:propofol+ketamine 2mg/kg/h+remifentanyl0.1ug/kg/h for maintence of general anesthesia
Sponsors
Anesthesiology Apartment of West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 to 60 years; 2. Elective operation; 3. The time of operation is about 1 to 3 hours; 4. ASA grades between I to II; 5. BMI between 18 to 24.
Exclusion criteria
Exclusion criteria: 1. Abnormal in liver or kidney; 2. Have contraindications to propofol, ketamine or remifentanyl; 3. Have medical history of neuropathy or psychosis such as epilepsy; 4. Have medical history of hypertension or heart disease; 5. The time of surgery prolong over three hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| dosage of propofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;blood pressure;the time of respiratory recovery;recovery time;Steward Score;the time in PACU;Intraoperative awareness;Fall asleep again;Delirium/Restless;nystagmus;Dizzy;dreams;Visual change;the acceptance of the patient;the propofol concentration in plasma when operation;the ketamine concentration in plasma when operation; | — |
Countries
China
Contacts
Public ContactLI Xiao Qiang
Outcome results
None listed