FindTrial
Sign In

Compiration of oral paracetamol and ibuprofen therapy for patent ductus arteriosus in preterm infants, a randomized controlled trial

Compiration of oral paracetamol and ibuprofen therapy for patent ductus arteriosus in preterm infants, a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-12002177
Enrollment
Unknown
Registered
2012-05-15
Start date
2012-05-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patent ductus arteriosus in preterm infants

Interventions

group A:oral paracetamol
group B:oral ibuprofen

Sponsors

The First Hospital of Jilin University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 1 Years

Inclusion criteria

Inclusion criteria: 1. Gestational age165 BPM; systolic murmur; pulmonary edema; metabolic; acidosis; bounding pulses; hepatosplenomegaly; (2) Hemodynamic significant (any one of the follows); 1) a left atrium to aortic root diameter ratio of >=1.4 in the parasternal long-axis view; 2) a DA diameter of >=1.4 mm/kg body weight; 3) left ventricular enlargement; 4) Holodiastolic flow reversal in the descending aorta.

Exclusion criteria

Exclusion criteria: 1. Congenital heart disease which need PDA to maintain blood flow; 2. Life-threatening infection; 3. Recent (within the previous 24 hours) intraventricular hemorrhage Grade 3-4; 4. Urine output 88.4umol/L; 6. Platelet count of <50*10^9/L; 7. Hyperbilirubinaemia which need exchange transfusion; 8. Active NEC and/or intestinal perforation.

Design outcomes

Primary

MeasureTime frame
The rate of ductal closure;side effects;complications;complication;—

Countries

China

Contacts

Public ContactHui Wu
wuhui97@126.com+86 431 88782771

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 10, 2026