elderly patient undergoing Intra-abdominal surgery
Conditions
Interventions
etomidate group:etomidate for anesthesia induction and maintenance
propofol group:propofol for anesthesia induction and maintenance
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. age from 60 to 90 year-old; 2. plan to undergo noncardiac surgery under general anesthesia with a duration of more than 2 hours; 3. agree to participate in this study.
Exclusion criteria
Exclusion criteria: 1. refuse to participate in the study; 2. history of schizophrenia, epilepsy, parkinsonism, and inability to communicate in the preoperative period; 3. history of adrenal cortex disaease, use of glucocortisol of more than 5 days in recent 1 year; 4. preoperative ASA >= grade IV; 5. severe hepatic or renal disease (Child-Pugh C grade; serum creatine > 442umol/L, with or without serum potassium > 6.5mmol/L or renal replacement therapy); 6. perioperative use of scopolamine or dexmedatomidine; 7)other situations unsuitable to participate in the study as judged by the attending anesthesiologists.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| occurrence of delirium during the first seven post; | — |
Secondary
| Measure | Time frame |
|---|---|
| the serum cortisol level after surgery;the occurrence of complications after surgery;the incidence of postoperative 30-day mortalit; | — |
Countries
China
Contacts
Public ContactDong-Xin Wang
Outcome results
None listed