Ischemic stroke
Conditions
Interventions
Two groups:Simvastatin : 40mg daily Atorvastatin : 40mg daily / 60 mg daily / 80 mg daily vs Simvastatin 10 mg for two years
Sponsors
None listed
Eligibility
Sex/Gender
Male
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Ischemic stroke patients aged 40-90; (2) MRI brain showing early confluent to confluent White Matter Lesion (Fazekas grading of 2 to 3; (3) LDL cholesterol level of >=3 mmol/L; (4) Sufficient Chinese competency for cognitive testing; (5) Informed written consent given.
Exclusion criteria
Exclusion criteria: (1) Stroke within 3 months of screening visit; (2) History of hemorrhagic stroke; (3) Dementia as defined by diagnostic and statistical manual, 4th edition (DSM-IV); (4) History of ischemic heart disease; (5) Severe stroke (Modified Rankin scale (mRS) of > = 5 or aphasia that hinders cognitive assessment; (6) Significant medical co-morbidities associated with limited life expectancy; (7) Change of lipid-altering drugs within 3 months of screening visit; (8) Other contraindications to statins e.g. Alanine transferase (ALT of > 20% of upper limit of normal; (9) elevated creatinine phosphokinae(CPK) level; 180*181mol/L or allergy to statins.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of MRI White Matter lesion Volume Time of measurement: Baseline, 1 year and 2 year MRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| (1)Change in other brain measures - lacunar infarcts - Microbleeds - brain volume - diffusion tensor imaging - breath holding index - pulsatility index;(2)Change in clinical measures - MoCA - Executive and memory tests - Instrumental activities of daily living [IADL] - Behavior - Gait Time of Measurement - Baseline, 1 year and 2 year visits; | — |
Countries
China
Contacts
Public ContactProfessor Vincent Mok
Outcome results
None listed