Gastroesophageal Reflux Disease (GERD)
Conditions
Interventions
Combined drugs treatment group:Deanxit, take 1 pill twice a day after breakfast and lunch each
Esomeprazole, take 40mg/day before breakfast.
one drug treatment group:Esomeprazole, take 40mg/day before breakfast.
Sponsors
Institute of Surgery Research, Daping Hospital, Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Male or female, age from 18 to 65; (2) Did not accept acid suppression therapy, use any sedative-hypnotic and anti-anxiety or depression products within past 2 weeks; (3) The diagnosis of GERD (GERDQ >=8; Gastroscopy shows reflux esophagitis or Barrett's Esophagus; PH determination prompts acid reflux; meet any of the conditions above)(ference to the standards of Los Angeles, the grading of reflux esophagitis under endoscopy are as follows: Class A lesions is confined to the esophageal mucosal folds, length 0.5cm; Class C lesions in the mucous membrane fusion at the top, but does not surround the entire esophageal wall; Class D lesions fusion with each other, and the range > 75% of the esophageal wall. Diagnosis of Barrett's Esophagus: pathology prompts intestinal metaplasia.); (4) HAD emotional determination, anxiety or depression score >=8; (5) Sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) The biochemical,endoscopic and other checks suggest peptic ulcer, gastrointestinal tumors, as well as diabetes, scleroderma, neurological diseases, severe liver diseases, heart disease, malignancy, and alcoholism; (2) Women who are pregnant or in lactation; (3) Participated in other clinical trials within three months before this; (4) Difficult to complete the follow-up or various of other factors affect the compliance; (5) Persons has an allergy to drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GerdQ; | — |
Countries
China
Contacts
Public ContactLan ChunHui
Outcome results
None listed