women undergoing IVF-ET cycles
Conditions
Interventions
Two groups:Subcutaneous injection of rLH or uhCG injection since day 6 of ovarian stimulation in IVF cycles until the day of ovulatory dose of hCG administration (the duration of participation depend
Sponsors
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. History of 2 episodes of poor ovarian response (less than 3 mature follicles on ovulatory dose of hCG or less than 3 mature oocytes retrieved) despite maximal stimulation; or 2. Patients fulfill two out of three of the following features: I.Age >=40 or any other risk factors: (1)History of ovarian surgery; (2)History of salpingectomy; (3)History of chemotherapy; (4)Present of ovarian endometrioma.
Exclusion criteria
Exclusion criteria: 1. Body mass index more than 30kg/m2; 2. Absent of one ovary; 3. History of polycystic ovarian disease; 4. Present of uterine abnormalities; 5. Present of endocrine/metabolic/autoimmune disease; 6. Incompetence or refuse for informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of mature oocytes retrieved on day of oocyte pick-up; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rates (defined as presence of intrauterine gestational sac with cardiac activity);Implantation rates (defined as number of gestational sacs / transferred embryos);Ongoing pregnancy rates (defined as pregnancy more than 12 weeks of gestation);Live birth rates (defined as delivery of live baby more than 24 weeks of gestation); | — |
Countries
China
Contacts
Public ContactDr. Cathy Hoi Sze CHUNG
Outcome results
None listed