Post-transplantation, Osteoporosis
Conditions
Interventions
Caltrate group:Caltrate
Ca-D joint group:Caltrate,Calcitriol
Ca-D group:Caltrate,Calcitriol
Alendronate group:Caltrate,Calcitriol
Sponsors
The General Hospital of Chinese People's Armed Police Forces
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. No less than 6 months after organ transplant; 2. Aged from 20 to 70 years old; 3. Knew the patients' right of informed consent of this trails, and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients allergic against Caltrate, Calcitriol, Alendronate and drug components accessories; 2. Patients,who use Active vitamin D in 2 months before the beginning of the study; 3. Subjects once treated with Alendronate, Sr salt, Sex hormones or Parathormone; 4. Suspected pregnancy or lactation; 5. Fracture occurred recently (3 months); 6. Active stage of cancer; 7. Abnormal esophageal emptying or activities of upper digestive tract ulcer; 8. Other metabolic bone disease except for osteoporosis; 9. Creatinine clearance rate <35 ml/min; 10. Life expectancy of less than 6 months; 11. Can't get informed consent because of delirium and dementia; 12. Not suitable for clinical trials because of other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bone mineral density; | — |
Secondary
| Measure | Time frame |
|---|---|
| beta-cross laps, CTX;total type I procollagen N-terminal peptide, P1NP;Parathormone, PTH;25(OH)D3;get-up and walk test;Serum electrolyte; | — |
Countries
China
Contacts
Public ContactXu Chun
Outcome results
None listed