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Influence of different source of n-3 fatty acid on plasma lipid in moderately hypercholesterolemia subject and the valid dosage

Influence of n-3 Polyunsaturated Fatty Acids on Plasma Lipid and Inflammatory Markers in Mild-to-Moderately Hypercholesterolemia Chinese Subjects and possible mechanism :A Placebo controlled, Random, double-blind and parallel study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-12002014
Enrollment
Unknown
Registered
2012-03-13
Start date
2009-07-16
Completion date
Unknown
Last updated
2018-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular disease

Interventions

1:Placebo
2:EPA/DHA 1.8g/d
3:EPA/DHA 3.6g/d
4:ALA 4g/d
5:ALA 8g/d

Sponsors

Facuty of Nutrition, Public Health Colleage, Sun-Yat Sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) mild to moderately hypercholesterolemia: TC: 5.13~8.00mmol/L, TG: 0.8-3.4mmol/L; 2) 40 to 65 years old; 3) BMI>23kg/m2.

Exclusion criteria

Exclusion criteria: People who had chronic inflammatory diseases, coronary heart disease, diabetics, other cardiovascular diseases, or were taking anti-inflammatory agents or other medications which could affect lipid metabolism.

Design outcomes

Primary

MeasureTime frame
plasma fatty acid composition;PBMCs fatty acid composition;IL-6 level of PBMCs supernatent;Percentage of CD14+ Cell which secrete IL-6/IL-1 a;—

Secondary

MeasureTime frame
Plasma TG/TC/HDL-c/LDL-c/VLDL-c;—

Countries

China

Contacts

Public ContactSu Yixiang

Guangzhou Medical University

suyx@mail.sysu.edu.cn+86 020 87331937

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026