symptomatic MCA stenosis
Conditions
Interventions
PTAS:stenting or balloon angioplasty
medical group:anti-platelet
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
27 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 25 and 75; 2. TIA or stroke in territory of unilateral MCA stenosis; 3. Stenosis >=70%, stenotic length 2mm; Atherosclerotic stenosis (with >=2 risk factors, such as hypertension, DM, hyperlipidemia, smoking, CHD, peripheral vessel diseases, atherosclerotic stenosis of >=20% of other vessels, or plaques on aorta); 4. NIHSS (National Institutes of Health Stroke Scale)=2radiologists consider the feasibility of endovascular treatment.
Exclusion criteria
Exclusion criteria: 1. Acute stroke in the target territory within 3 weeks before registered;Large area of stroke, involving one third of the target vascular territory on imaging; 2. Tandem >=50% stenosis of target MCA,Tortuous or angulated target segment of MCA or other factors which make it difficult to deliver endovascular treatment; 3. Have undergone angioplasty (with or without stenting) at the target vessel before randomization; 4. Have received thrombolysis treatment within 24 hours before randomization; 5. High risk of bleeding, especially for gastrointestinal ulcers; 6. Combined with other malignant diseases that can survive no more than one year; 7. Acute dissection, vasculitis, Moyamoya disease, radiation related vessel diseases, or muscle dysplasia; 8. Calcified plaque difficult to be diluted, or embolism in target lumen, or poor perfusion of distal diffusion; 9. Intracranial hemorrhage or hemorrhagic stroke in the territory of the stenotic artery within30 days; 10. Concurrent intracranial tumors, cerebral arteriovenous malformations, or aneurysms (except unruptured aneurysms 1.5 (irreversible) and uncorrectable bleeding diathesis; 14. Have received serious surgery within 30 days before randomization or intend to undergo serious surgery within 90 days after randomization; 15. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ischemic event; | — |
Countries
China
Contacts
Public ContactMiao Zhongrong
Outcome results
None listed