Nasopharyngeal Carcinoma
Conditions
Interventions
A:cisplatin CCRT every three weeks
B:cisplatin CCRT every week
Sponsors
Nasopharyngeal Carcinoma Department of Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Histologic diagnosis of nasopharyngeal carcinoma; 2. Aged between 18 and 65 years; 3. T3N0-2M0, T4N0-2M0, T1-4N2M0(UICC 7th edition); 4. KPS>=80; 5. No distant metastasis; 6. WBC count>=4*10^9/L, Hemoglobin>=100g/L, platelet count>=100*10^9/L; 7. ALT or AST<2*ULN, bilirubin<1.5*ULN; 8. Serum creatinine<1.5*ULN.
Exclusion criteria
Exclusion criteria: 1. Distant metastases; 2. Previously treated (surgery, chemotherapy, radiotherapy, EGFR targeted therapy or immunotherapy); 3. Second malignancy within 5 years; 4. Precious therapy with an investigational agent; 5. Uncontrolled seizure disorder or other serious neurologic disease; 6. Allergic reaction (>=Grade III) to any drug including in this study; 7. Clinically significant cardiac or respiratory disease; 8. Creatinine clearance <30ml/min; 9. Drug or alcohol addiction; 10. Do not have full capacity for civil acts; 11. With severe complications or active infection; 12. Concurrent immunotherapy or hormone therapy for other diseases; 13. Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| failure free survive rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival rate;locoregional failure-free rate;disease free survival rate;distant metastasis free survival;Quality of life; | — |
Countries
China
Contacts
Public ContactGuo Xiang
Outcome results
None listed