Benign prostatic hyperphasia
Conditions
Interventions
A:Weight reduction program supervised by physician, dietitian and physiotherapist for 48 weeks.
B:Weight reduction advice for 48 weeks
Sponsors
Urology Division, Department of Surgery, CUHK
Eligibility
Sex/Gender
Male
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male patient with aged >=50 years old; 2. Defined as obese, with BMI > 25 Kg/m2l; 3. With moderate to severe lower urinary tract symptom (IPSS >7); 4. Maximum flow rate between 5 – 15 ml/s; 5. Post-void residual urine 30 cc.
Exclusion criteria
Exclusion criteria: 1. Patients considered as extreme obese, with BMI >35 Kg/m2; 2. Patients with LUTS due to urethral stricture, neurogenic bladder or other structural abnormality; 3. Patients with long-term catheterization or who perform intermittent self-catheterization ? Patients with known history of prostate cancer or bladder cancer at the time of assessment; 4. Patients with on 5a-reductase inhibitors, phytotherapy, or other hormonal therapy; 5. Patients with history of prostatic / bladder surgery or other pelvic surgery that may affect voiding; 6. Patients with bladder stones or an active urinary tract infection at the time of assessment; 7. Patient do not tolerate tamsulosin OCAS for the management of LUTS; 8. Patient with poor cardiac status (NYHA class III or above) or other medical conditions that are not suitable for intense exercise or weight reduction programme.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in total score of International Prostate Symptom Score (IPSS) at the end of trial (52 weeks),;maximum flow rate (Qmax);total irritative symptom score of IPSS (Q2, 4 & 7);number of nocturia;QoL score;PSA level;prostate volume; | — |
Countries
China
Contacts
Public ContactProf. Ng, Chi Fai
Outcome results
None listed