Hypotension After Induction of General Anesthesia
Conditions
Interventions
methoxamine group:when anesthesia induced,preload methoxamine
ephedrine group:when anesthesia induced,preload ephedrine
NS group:when anesthesia induced, preload NS
Sponsors
Anesthesia department, Wuhan Union Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: ASA1-3, Elective surgery, general anesthesia, no cardiac surgery, age >=60; Hypertensive patients with baseline systolic blood pressure<=180mmHg or baseline diastolic blood pressure<=110mmHg; Sign the ICF, voluntary to paticipate and could coordinate.
Exclusion criteria
Exclusion criteria: Allergic to methoxamine and ephedrine; ASA>=4; With serious cardiovascular disease, NYHA>=3; Nearly six months have cerebrovascular accident, myocardial infarction; Malignant arrhythmia; Coronary heart disease patients; Serious valve disease; Serious systemic chronic disease (such as hyperthyroidism, copd, diabetes) without good control; Badly damaged liver and kidney function (Tbil > 1.5 ULN, ALT > 2 ULN or AST, Cr > 1 ULN); Have serious electrolytes disturbance; Moderate to severe anemia patients (Hb < 90 g/L); Basic heart rate < 50 / minutes; With Secondary high blood pressure; Intubation time more than 60 seconds; Pregnancy or lactation women; Participate other clinical drug test during nearly 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;CI/C; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate; | — |
Countries
China
Contacts
Public ContactQingping Wu
Outcome results
None listed