bacterial lower respiratory tract and urinary tract infections
Conditions
Interventions
Biapenem group:biapenem versus meropenem
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inpatients and a few outpatients aged from 18 to 70 years old, regardless of their gender and ethnicity, who were diagnosed of either lower respiratory tract infections or UTIs (including acute episodes of chronic infections) caused by bacteria were eligible for the study. In additional to symptoms, signs and laboratory results, lower respiratory infections should be proven by radiography, and UTIs must be upper urinary tract infections or complicated urinary tract infections. Meanwhile, enrollment of patients with healthcare-associated infections was encouraged.
Exclusion criteria
Exclusion criteria: Patients must either not have had received antimicrobial therapy within 48 hours before study enrollment or may have had received ineffective antimicrobial therapy proven by clinical response and positive culture. Patients with any of the following conditions were excluded: history of hypersensitivity to ß-lactams; serum creatinine level above the upper limit of the normal range or creatinine clearance 1.5 times of the upper limit of the normal range; severe cardiac or haematological abnormalities; terminal malignancy; central nervous system illness or immunodeficiency; complex infections that needed combination therapy with other antimicrobial drugs; pregnant or lactating woman; psychiatric illness; or non-bacterial infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bacteriological efficacy; | — |
Countries
China
Contacts
Public ContactLv Xiaoju
Outcome results
None listed