liver cirrhosis
Conditions
Interventions
TUDCA group:750mg/d, oral
UDCA group:750mg/d, oral
Sponsors
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: cirrhosis based on the standard criteria revised at 2000 by the branch of infectious, parasitic diseases and hepatic association of Chinese medical association; age between 18 and 75 years; written informed consent.
Exclusion criteria
Exclusion criteria: Body mass index (BMI)>28kg/m2; serum total bilirubin concentration >=171umol/L; hepatic failure who need hepatic transplantation; malignancies; gallbladder disease; active gastrointestinal bleeding; hepatic encephalopathy; hepatorenal syndrome; intestinal infection; peptic ulcer; severe heart and renal dysfunction; severe endocrine, hematologic and neuropsychiatric diseases; pregnancy or lactation. Patients were also excluded if they had been treated with interferon, UDCA, colchicine, anti-virus or immunomodulatory drugs in the previous 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| alanine aminotransferase;aspartate aminotransferase;alkaline phosphatase;gamma-glutamyltransferas; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum markers of liver fibrosis;liver histologic stage; | — |
Countries
China
Contacts
Public ContactXiaohua Hou
Outcome results
None listed